1H-benzimidazol-2-ylmethylamine dihydrochloride

1H-benzimidazol-2-ylmethylamine dihydrochloride - Names and Identifiers

Name	(1H-BENZO[D]IMIDAZOL-2-YL)METHANAMINE
Synonyms	2-aminomethylbenzimidazole 2-benzimidazolylmethylamine 1h-benzimidazole-2-methanamine 1H-benzimidazol-2-ylmethanamine 1-(1H-BENZIMIDAZOL-2-YL)METHANAMINE (1H-BENZO[D]IMIDAZOL-2-YL)METHANAMINE 1H-benzimidazol-2-ylmethylamine dihydrochloride
CAS	5805-57-2

1H-benzimidazol-2-ylmethylamine dihydrochloride - Physico-chemical Properties

Molecular Formula	C8H9N3
Molar Mass	147.18
Density	1.278±0.06 g/cm3(Predicted)
Melting Point	101.5 °C
Boling Point	384.3±25.0 °C(Predicted)
pKa	12.24±0.29(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C

1H-benzimidazol-2-ylmethylamine dihydrochloride - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Class	IRRITANT

1H-benzimidazol-2-ylmethylamine dihydrochloride - Reference Information

Introduction

(1H-benzimidazole-2-methylene) amine is also called 2-aminomethylbenzimidazole. 2-Aminomethyl benzimidazole derivative is an important fine chemical raw material. Due to the strong coordination ability of organic compounds containing benzimidazole functional groups and the diversity of coordination configurations, the coordination chemistry of benzimidazole ligands has become a very active research topic.

preparation method

weigh 1.08g of o-phenylenediamine and 1.12g of glycine into a 20mL autoclave, add 14mL of HCl of 6mol/L, stir evenly, place in a 120 ℃ incubator for 48 hours, cool, adjust the pH of concentrated ammonia water to about 8, cool to below 4 ℃, precipitate solid, filter, and recrystallize the product with water for distillation, add activated carbon for decolorization to obtain colorless needle (1H-benzimidazole-2-methylene) amine with 72% yield.

Last Update：2024-04-09 19:05:05